Indomethacin-induced hyperkalemia in three patients with gouty arthritis.

Abstract

We describe three patients in whom severe, life-threatening hyperkalemia and renal insufficiency developed after treatment of acute gouty arthritis with indomethacin. This complication may result from an inhibition of prostaglandin synthesis and consequent hyporeninemic hypoaidosteronism. Careful attention to renal function and potassium balance in patients receiving indomethacin or other nonsteroidal anti-inflammatory agents, particularly in those patients with diabetes mellitus or preexisting renal disease, will help prevent this potentially serious complication.

• Authors: J W Findling, D Beckstrom, L Rawsthorne, F Kozin, H Itskovitz
• Journal: JAMA (JAMA) Vol. 244 Issue 10 Pg. 1127-8 (Sep 05 1980) ISSN: 0098-7484 [Print] United States
• PMID: 7411769 (Publication Type: Case Reports, Journal Article)

Chemical References

• Uric Acid
• Indomethacin

Topics

• Acute Disease
• Acute Kidney Injury (chemically induced)
• Aged
• Diabetes Mellitus (physiopathology)
• Female
• Gout (drug therapy, physiopathology)
• Humans
• Hyperkalemia (chemically induced)
• Indomethacin (adverse effects)
• Male
• Middle Aged
• Nephritis, Interstitial (physiopathology)
• Uric Acid (blood)