Bioconversion and biosynthesis of nanaomycins using cerulenin, a specific inhibitor of fatty acid and polyketide biosyntheses.

Abstract

The biosynthetic relationship of the nanaomycins produced by Streptomyces rosa var. notoensis OS-3966 was studied by means of a bioconversion method using the antibiotic cerulenin, a specific inhibitor of fatty acid and polyketide biosyntheses. Nanaomycin D was considered to be the first component produced from the hypothetical intermediate "polyketide". It is proposed that the biosynthesis sequence for the nanaomycin is: nanaomycin D leads to nanaomycin A leads to nanaomycin E leads to nanaomycin B. Nanaomycin B can be converted to nanaomycin A by non-enzymatic dehydration; however, nanaomycin A is rapidly bioconverted to nanaomycin E, which is the major component synthesized by the nanaomycin-producing strain.

• Authors: C Kitao, H Tanaka, S Minami, S Omura
• Journal: The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 33 Issue 7 Pg. 711-6 (Jul 1980) ISSN: 0021-8820 [Print] England
• PMID: 7410214 (Publication Type: Journal Article)

Chemical References

• Antifungal Agents
• Fatty Acids
• Naphthoquinones
• Cerulenin
• nanaomycin A
• nanaomycin B
• nanaomycin C
• nanaomycin E
• kalafungin

Topics

• Antifungal Agents (biosynthesis, metabolism, pharmacology)
• Biotransformation
• Cerulenin (pharmacology)
• Fatty Acids (metabolism)
• Naphthoquinones (biosynthesis, metabolism)
• Streptomyces (growth & development, metabolism)
• Time Factors