Tatumine, a peptide from Bacillus brevis Vm4-572-403.

Abstract	The mutant 572-403 of Bacillus brevis Vm4 was isolated from N-methyl-N'-nitro-N-nitroso guanidine (nitrosoguanidine)-treated cultures of the parental strain. The mutant produces tatumine and edeine B when grown in a defined medium at 40 degrees C. Tatumine is composed of spermidine, glycine, isoserine, and an unidentified ninhydrin-positive compound; it has a molecular weight of less than 730 d (edeine A). It is soluble in water and isopropanol. Tatumine has no antimicrobial activity but has selective cytotoxicity against cultured cells of sarcoma origin. This activity is not destroyed by heating for 1 hour at 60 degrees C.
Authors	J Heaney-Kieras, Z Kurylo-Borowska
Journal	The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 33 Issue 4 Pg. 359-63 (Apr 1980) ISSN: 0021-8820 [Print] England
PMID	7410204 (Publication Type: Journal Article)
Chemical References	Anti-Bacterial Agents Antibiotics, Antineoplastic Intercellular Signaling Peptides and Proteins Peptides tatumine
Topics	Animals Anti-Bacterial Agents Antibiotics, Antineoplastic (isolation & purification) Bacillus (analysis) Cells, Cultured Chemical Phenomena Chemistry Chemistry, Physical Humans Intercellular Signaling Peptides and Proteins Mutation Peptides (isolation & purification)

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