Baker's antifol in combination with 5-fluorouracil and methyl-CCNU in the treatment of metastatic colorectal cancer: a Southwest Oncology Group Study (Protocol 7764).

Abstract

Fifty-one previously untreated patients with metastatic colorectal cancer were treated with a combination of 5-fluorouracil, methyl-CCNU, and Baker's antifol. Six of 34 fully evaluable patients achieved a response. There were no apparent benefits obtained with this combination compared to treatment with 5-fluorouracil alone.

• Authors: M T Shaw, J D Bonnet, H Wilson, L K Heilbrun
• Journal: Cancer treatment reports (Cancer Treat Rep) 1980 Feb-Mar Vol. 64 Issue 2-3 Pg. 247-50 ISSN: 0361-5960 [Print] United States
• PMID: 7407758 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Folic Acid Antagonists
• Nitrosourea Compounds
• Triazines
• Semustine
• triazinate
• Fluorouracil

Topics

• Adult
• Aged
• Blood Cell Count
• Colonic Neoplasms (drug therapy, pathology)
• Drug Administration Schedule
• Drug Therapy, Combination
• Female
• Fluorouracil (administration & dosage)
• Folic Acid Antagonists (administration & dosage)
• Humans
• Male
• Middle Aged
• Neoplasm Metastasis
• Nitrosourea Compounds (administration & dosage)
• Prognosis
• Rectal Neoplasms (drug therapy, pathology)
• Semustine (administration & dosage)
• Time Factors
• Triazines (administration & dosage)