Subacute toxicity of Dietary T-2 toxin in mice: influence of protein nutrition.

Abstract

The subacute toxic effects of dietary T-2 toxin (20 ppm) incorporated in semipurified diets of 8%, 12% or 16% protein, were examined in young Swiss mice after one, two, three and four weeks. Dietary T-2 toxin caused substantial reductions in growth and food consumptaion, the degrees of which were greatest in mice fed the diets of reduced protein content. T-2 toxin consistently caused similar degrees of nonregenerative anemia, lymphopenia, thymic atrophy and gastric hyperkeratosis irrespective of the dietary protein level. However, erythroid hypoplasia was temporary in mice fed T-2 toxin in the 16%-protein diet such that erythroid precursors regenerated in splenic and bone marrow and were hyperplastic after four weeks. Liver to body weight ratios of mice fed T-2 toxin in the 16%-and 12%-protein diets increased during the four week trial in comparison to control mice fed at a similar rate. These observations indicated that suppression of erythropoiesis in mice by dietary T-2 toxin was temporarty and that the interval before regeneration was prolonged by diets of reduced protein content.

• Authors: M A Hayes, H B Schiefer
• Journal: Canadian journal of comparative medicine : Revue canadienne de medecine comparee (Can J Comp Med) Vol. 44 Issue 2 Pg. 219-28 (Apr 1980) ISSN: 0008-4050 [Print] Canada
• PMID: 7407693 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Dietary Proteins
• Sesquiterpenes
• T-2 Toxin

Topics

• Animal Feed
• Animals
• Body Weight
• Dermatitis (pathology, veterinary)
• Dietary Proteins (administration & dosage, metabolism)
• Erythropoiesis
• Male
• Mice
• Rodent Diseases (metabolism, pathology)
• Sesquiterpenes (toxicity)
• Spleen (pathology)
• Stomach (pathology)
• T-2 Toxin (toxicity)