[Experimental study of the allergic properties of tomicide. The allergic properties of the native preparation].

Abstract	The allergenic properties of thomycide, an antibacterial substance produced by Streptococcus sp., Thom-1606 active against Streptococci, Staphylococci and Ps. aeruginosa were studied in the reactions of hypersensitivity of immediate (HIT) and delayed (HRT) types. It was found that thomycide induced no HIT in guinea-pigs sensitized with the preparation. The reaction of HRT was slightly pronounced in the animals and must be defined by the nutrient medium used for the strain growth. Preliminary exposure of the animals to thomycide resulted in lower levels of anaphylactic reactions in the animals sensitized with cattle serum.
Authors	L P Blinkova, V N Efremova
Journal	Antibiotiki (Antibiotiki) Vol. 25 Issue 7 Pg. 528-31 (Jul 1980) ISSN: 0003-5637 [Print] Russia (Federation)
Vernacular Title	Eksperimental'noe izuchenie allergicheskikh svoĭsty tomitsida. Allergicheskie svoĭstva nativnogo preparata.
PMID	7406465 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References	Anti-Bacterial Agents Bacteriocins tomicide
Topics	Anaphylaxis (chemically induced) Animals Anti-Bacterial Agents (immunology) Bacteriocins Dose-Response Relationship, Immunologic Drug Hypersensitivity (immunology) Guinea Pigs Hypersensitivity, Delayed (chemically induced) Hypersensitivity, Immediate (chemically induced) Immunization Skin Tests

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