[Rare liver damage caused by an antihypertensive and anti-arrhythmic agents].

Abstract

It is reported on lesions of the liver parenchyma after the application of dihydralazin and detajmium bitartrate with description of the clinical and morphological findings. By means of the morphological findings got in liver biopsy a clinically supposed acute virus hepatitis could be excluded. After the application of dihydralazin group cell necroses and an inflammation of the periportal fields, after detajmium bitartrate a typical intrahepatic cholestasis was in the front. The knowledge of medicamentous side-effects may avoid diagnostic and therapeutic errors in the individual case.

• Authors: K Mölleken, K Rüger
• Journal: Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete (Z Gesamte Inn Med) Vol. 35 Issue 7 Pg. 296-9 (Apr 01 1980) ISSN: 0044-2542 [Print] Germany
• Vernacular Title: Seltene Leberschäden durch Antihypertensiva und Antiarrhythmika.
• PMID: 7405322 (Publication Type: Case Reports, Journal Article)

Chemical References

• Ajmaline
• Hydralazine
• Dihydralazine

Topics

• Adult
• Ajmaline (adverse effects)
• Biopsy
• Chemical and Drug Induced Liver Injury (etiology, pathology)
• Cholestasis, Intrahepatic (chemically induced)
• Dihydralazine (adverse effects)
• Female
• Humans
• Hydralazine (analogs & derivatives)
• Liver (pathology)
• Necrosis (chemically induced)