Nifedipine for digitalis-induced arrhythmias.

Abstract

The calcium antagonist, nifedipine (Adalat; Bayer), has previously been thought by most workers to lack cardiac-anti-arrhythmic properties, thus differing from verapamil. We have found that nifedipine was successful in converting cardiac glycoside (K-strophanthoside)-induced ventricular tachycardia to sinus rhythm in 4 of 5 anaesthetized dogs when given intravenously. In this respect, therefore, nifedipine is similar to verapamil. Further work is advocated before applying these results to the clinical situation in man.

• Authors: F H Spracklen, L H Lazarus
• Journal: South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde (S Afr Med J) Vol. 57 Issue 25 Pg. 1046 (Jun 21 1980) ISSN: 0256-9574 [Print] South Africa
• PMID: 7404089 (Publication Type: Journal Article)

Chemical References

• Pyridines
• Strophanthins
• Phenytoin
• Verapamil
• Nifedipine

Topics

• Animals
• Arrhythmias, Cardiac (chemically induced, drug therapy)
• Dogs
• Nifedipine (therapeutic use)
• Phenytoin (therapeutic use)
• Pyridines (therapeutic use)
• Strophanthins (pharmacology)
• Verapamil (therapeutic use)