Rapid-eye-movement sleep deprivation decreases the density of 3H-dihydroalprenolol and 3H-imipramine binding sites in the rat cerebral cortex.

Abstract

The high affinity binding sites for 3H-imipramine (3H-IMI) and 3H-dihydroalprenolol (3H-DHA) in the rat cerebral cortex were studied after 2,4 48 and 72 h of rapid-eye-movement (REM) sleep deprivation. Both the Kd and Bmax values for 3H-IMI and 3H-DHA binding remained unaffected after 24 or 48 h of REM sleep deprivation. After 72 or REM sleep deprivation there was a significant reduction in the Bmax for 3H-IMI and 3H-DHA binding with a concomitant increase in the apparent affinities. The reduction in high affinity 3H-IMI and 3H-dihydroalprenolol binding sites observed 72 h after REM sleep deprivation could be related to the antidepressant effects of REM sleep deprivation in man.

• Authors: E Mogilnicka, S Arbilla, H Depoortere, S Z Langer
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 65 Issue 2-3 Pg. 289-92 (Jul 25 1980) ISSN: 0014-2999 [Print] Netherlands
• PMID: 7398791 (Publication Type: Journal Article)

Chemical References

• Dihydroalprenolol
• Alprenolol
• Imipramine

Topics

• Alprenolol (analogs & derivatives)
• Animals
• Binding Sites
• Cerebral Cortex (metabolism)
• Dihydroalprenolol (metabolism)
• Imipramine (metabolism)
• Male
• Rats
• Sleep, REM (physiology)
• Time Factors