The alpha-naphthoxyacetic acid-elicited retching involves dopaminergic inhibition in mice.

Abstract

Alpha-naphthoxyacetic acid (alpha-NOAA), one of the jumping-inducers, elicited a dose-dependent retching behavior at doses ranging from 250 to 550 mg/kg in mice and vomiting at a dose of 550 mg/kg in pigeons. Protoveratrine-A (PV-A, 0.1 mg/kg), a veratrum alkaloid, also induced retching in mice and vomiting in pigeons, while apomorphine (2 mg/kg) produced neither retching in mice nor vomiting in pigeons though it induced feeding in pigeons. The retching elicited by alpha-NOAA or PV-A was not significantly affected by scopolamine, aminooxyacetic acid and gamma-butyrolactone, but was markedly inhibited by apomorphine (2 mg/kg), this inhibitory effect being antagonized without significance by haloperidol which did not itself augment the retching. These results imply that the retching elicited by alpha-NOAA or PV-A seems to involve at least in part an inhibition of dopaminergic neuron activity.

• Authors: T Furukawa, K Yamada
• Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav) Vol. 12 Issue 5 Pg. 735-8 (May 1980) ISSN: 0091-3057 [Print] United States
• PMID: 7393967 (Publication Type: Journal Article)

Chemical References

• Dopamine Antagonists
• Glycolates
• Naphthalenes
• Protoveratrines
• 1-naphthoxyacetic acid
• Apomorphine

Topics

• Animals
• Apomorphine (pharmacology)
• Behavior, Animal (drug effects)
• Columbidae
• Dopamine Antagonists
• Glycolates (pharmacology)
• Male
• Mice
• Motor Activity (drug effects)
• Naphthalenes (pharmacology)
• Neurons (drug effects)
• Protoveratrines (pharmacology)
• Vomiting (chemically induced)