Drug trials: treatment of urinary tract infection with multiple-dose intramuscular administration of cephamandole.

Abstract

Therapy with cephamandole (1.0 g, every eight hours) for five days was effective in eliminating cephamandole-sensitive microorganisms from the urinary tract. A 75% cure rate was achieved in a group of 20 patients, 45% of whom had abnormalities of the urinary tract. Local pain (despite addition of lignocaine) was sufficiently prolonged and severe to make multiple-dose intramuscular administration unacceptable. No other toxic effects were encountered.

• Authors: A Nankervis, K F Fairley, P Shaw, J A Whitworth, H Miles, I Graham, R Pavillard
• Journal: The Medical journal of Australia (Med J Aust) Vol. 1 Issue 9 Pg. 427-8 (May 03 1980) ISSN: 0025-729X [Print] Australia
• PMID: 7393095 (Publication Type: Journal Article)

Chemical References

• Anti-Infective Agents, Urinary
• Cephalosporins
• Cefamandole

Topics

• Anti-Infective Agents, Urinary (administration & dosage, metabolism)
• Cefamandole (administration & dosage, metabolism)
• Cephalosporins (administration & dosage)
• Enterobacteriaceae Infections (drug therapy)
• Female
• Humans
• Injections, Intramuscular (adverse effects)
• Male
• Middle Aged
• Pain (etiology)
• Staphylococcal Infections (drug therapy)
• Urinary Tract Infections (drug therapy)