Immunopotentiation by pyrimethamine in the mouse.

Abstract	Pyrimethamine, a 2,4-diaminopyrimidine useful in the treatment of malaria and toxoplasmosis, was found to enhance antibody and delayed-type hypersensitivity responses to sheep red cells in mice. The immunodepression of tumour-bearing mice was also reversed by pyrimethamine. This drug may prove useful as a general immunostimulant in clinical situations where the immune system has been compromised by cancer or other debilitating illnesses.
Authors	Y H Thong, A Ferrante
Journal	Clinical and experimental immunology (Clin Exp Immunol) Vol. 39 Issue 1 Pg. 190-4 (Jan 1980) ISSN: 0009-9104 [Print] England
PMID	7389192 (Publication Type: Journal Article)
Chemical References	Adjuvants, Immunologic Pyrimethamine
Topics	Adjuvants, Immunologic Animals Antibody Formation (drug effects) Dose-Response Relationship, Drug Hypersensitivity, Delayed Male Melanoma (immunology) Mice Mice, Inbred Strains Neoplasms, Experimental (immunology) Pyrimethamine (pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!