Lithium effects: protection against nitrogen narcosis, potentiation of HPNS.

Abstract

The effect of either 10, 8, or 6 meq/kg of intraperitoneal lithium chloride or sodium chloride on the loss of righting response (RR50) produced by 18.2 ATA N2-ATA O2 was examined in rats. Results were compared to the effects of 10, 8, 6, or 4 meq/kg of intraperitoneal lithium chloride given 24 h before determination of the convulsion pressure (PC) in 40 rats compressed with He-O2 at 160 atm/h at 37 +/- 0.5 degrees C. Lithium (10 meq/kg) prevented the nitrogen-narcosis-induced loss of righting response but significantly potentiated the pressure (depth) at which convulsions and tremors occurred.

• Authors: P B Bennett, B L Leventhal, R Coggin, J Roby, L Racanska
• Journal: Undersea biomedical research (Undersea Biomed Res) Vol. 7 Issue 1 Pg. 11-6 (Mar 1980) ISSN: 0093-5387 [Print] United States
• PMID: 7385444 (Publication Type: Journal Article)

Chemical References

• Lithium

Topics

• Animals
• Hydrostatic Pressure (adverse effects)
• Inert Gas Narcosis (drug therapy)
• Lithium (therapeutic use)
• Rats