HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Spontaneous cytotoxicity of murine cells treated with the interferon inducers BRL 5907 and BRL 10739.

Abstract
The effects of the polyribonucleotide interferon inducers, BRL 5907 and BRL 10739, on the spontaneous cytotoxicity of CBA mouse cells towards the allogeneic lymphoma EL-4, were investigated. Intravenous administration of BRL 5907 and BRL 10739 increased the cytotoxic activity of a non-adherent, theta-negative, surface immunoglobulin-negative cell present in the spleen, but had no effect on cells in the lymph nodes. Spleen cell cytotoxicity was established within 24 h of injection of the polyribonucleotides, but had disappeared by 4 days. In addition, injection of mice with BRL 10739 increased the spontaneous cytotoxicity of a nylon-wool-adherent, theta-positive spleen cell. Intraperitoneal injection of mice with BRL 5907 and BRL 10739 also enhanced the cytotoxic activity of a non-adherent peritoneal exudate cell.
AuthorsR M Cook
JournalImmunology (Immunology) Vol. 39 Issue 2 Pg. 151-7 (Feb 1980) ISSN: 0019-2805 [Print] England
PMID7380465 (Publication Type: Journal Article)
Chemical References
  • Interferon Inducers
  • Quaternary Ammonium Compounds
  • RNA, Double-Stranded
  • RNA, Viral
  • BRL 5907
  • BRL 10739
Topics
  • Animals
  • Ascitic Fluid (immunology)
  • Cytotoxicity, Immunologic (drug effects)
  • Interferon Inducers (pharmacology)
  • Lymph Nodes (immunology)
  • Lymphoma (immunology)
  • Male
  • Mice
  • Mice, Inbred CBA
  • Neoplasms, Experimental (immunology)
  • Quaternary Ammonium Compounds (pharmacology)
  • RNA, Double-Stranded (pharmacology)
  • RNA, Viral (pharmacology)
  • Spleen (immunology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: