Esophageal carcinoma in rats induced by N-amyl-N-methylnitrosamine.

Abstract

N-Amyl-N-methylnitrosamine (AMN) induced esophageal carcinoma in Donryu strain rats when given in drinking water. The incidence of carcinomas was high when AMN was given as 0.0015% solution for 90 days or 0.003% solution for 60 days. There was no difference in the incidence in males and females. Sequential studies showed that 4-week administration was necessary to induce esophageal papillomas, and 8-week administration to induce esophageal carcinomas. Whole-body autoradiography after intravenous injection of N-amyl-N-methyl[14C]-nitrosamine (14C-AMN) indicated that AMN accumulated preferentially in the esophagus.

• Authors: T Iizuka, S Ichimura, T Kawachi
• Journal: Gan (Gan) Vol. 71 Issue 1 Pg. 94-9 (Feb 1980) ISSN: 0016-450X [Print] Japan
• PMID: 7380140 (Publication Type: Journal Article)

Chemical References

• Carcinogens
• Nitrosamines
• N-amyl-N-methylnitrosamine

Topics

• Age Factors
• Animals
• Autoradiography
• Carcinogens (metabolism, toxicity)
• Carcinoma (chemically induced)
• Esophageal Neoplasms (chemically induced, pathology)
• Esophagus (pathology)
• Female
• Male
• Neoplasms, Experimental (chemically induced)
• Nitrosamines (metabolism, toxicity)
• Papilloma (chemically induced)
• Rats
• Time Factors
• Tissue Distribution