BAEE esterase (kallikrein-like) activity in parotid saliva of normal rats and rats with various forms of experimental hypertension (genuine, renovascular and DOCA salt hypertension).

Abstract

A technique for continuous and quantitative collection of parotid saliva including salivary flow rate determination for in vitro experiments in rats is described. Kallikrein-like activity in parotid saliva of rats with various forms of arterial hypertension (genuine, renovascular and DOCA salt hypertension) was studied. Kallikrein-like excretion was measured by its estoerolytic activity using benzoyl arginine ethyl ester (BAEE) as a substrate. The levels of kallikrein-like activity in parotid saliva of normotensive control rats ranged between 2.5 and 4.0 mU/min during salivary flow stimulation with pilocarpine. In all forms of experimental hypertension kallikrein-like activity in saliva was increased two-to fourfold. This increase was not related to the activity of the renin-angiotensin system.

• Authors: G Schmid, N Neff, K Hempel, A Heidland
• Journal: Contributions to nephrology (Contrib Nephrol) Vol. 19 Pg. 124-33 ( 1980) ISSN: 0302-5144 [Print] Switzerland
• PMID: 7379530 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Desoxycorticosterone
• Arginine
• Carboxylic Ester Hydrolases
• benzoylarginine ethyl esterase

Topics

• Animals
• Arginine (analogs & derivatives, metabolism)
• Carboxylic Ester Hydrolases (metabolism)
• Desoxycorticosterone
• Disease Models, Animal
• Hypertension (chemically induced, enzymology)
• Hypertension, Renal (enzymology)
• Hypertension, Renovascular (enzymology)
• Male
• Parotid Gland (enzymology)
• Rats
• Saliva (enzymology)