Abstract |
Twenty-five patients undergoing microlaryngoscopy were anaesthetized with thiopentone and nitrous oxide with suxamethonium as a muscle relaxant. Thirteen received practolol 0.4 mg kg-1 and atropine 1.5 mg i.v. shortly before anaesthesia. During anaesthesia practolol 0.2 mg kg-1 was given. Twelve (control) received atropine 0.5 mg before anaesthesia. Practolol reduced the frequency of tachycardia and arrhythmia. The treatment group had a greater reduction in systolic arterial pressure during induction. The hypertensive response to laryngoscopy was not significantly attenuated by practolol. A weak hyperglycaemic response to microlaryngoscopy was not affected, nor was the plasma concentration of glycerol.
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Authors | O Werner, J Magnusson, R Fletcher, P Nilsson-Ehle, O Pahlm |
Journal | British journal of anaesthesia
(Br J Anaesth)
Vol. 52
Issue 1
Pg. 91-6
(Jan 1980)
ISSN: 0007-0912 [Print] England |
PMID | 7378234
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Blood Glucose
- Glycerol
- Practolol
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Topics |
- Aged
- Anesthesia, General
- Blood Glucose
(metabolism)
- Blood Pressure
(drug effects)
- Female
- Glycerol
(blood)
- Heart Rate
(drug effects)
- Humans
- Injections, Intravenous
- Intraoperative Period
- Laryngoscopy
- Male
- Microsurgery
- Middle Aged
- Practolol
(administration & dosage, pharmacology)
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