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I.V. practolol during microlaryngoscopy. Effect on arterial pressure, heart rate, blood glucose and lipolysis.

Abstract
Twenty-five patients undergoing microlaryngoscopy were anaesthetized with thiopentone and nitrous oxide with suxamethonium as a muscle relaxant. Thirteen received practolol 0.4 mg kg-1 and atropine 1.5 mg i.v. shortly before anaesthesia. During anaesthesia practolol 0.2 mg kg-1 was given. Twelve (control) received atropine 0.5 mg before anaesthesia. Practolol reduced the frequency of tachycardia and arrhythmia. The treatment group had a greater reduction in systolic arterial pressure during induction. The hypertensive response to laryngoscopy was not significantly attenuated by practolol. A weak hyperglycaemic response to microlaryngoscopy was not affected, nor was the plasma concentration of glycerol.
AuthorsO Werner, J Magnusson, R Fletcher, P Nilsson-Ehle, O Pahlm
JournalBritish journal of anaesthesia (Br J Anaesth) Vol. 52 Issue 1 Pg. 91-6 (Jan 1980) ISSN: 0007-0912 [Print] England
PMID7378234 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Blood Glucose
  • Glycerol
  • Practolol
Topics
  • Aged
  • Anesthesia, General
  • Blood Glucose (metabolism)
  • Blood Pressure (drug effects)
  • Female
  • Glycerol (blood)
  • Heart Rate (drug effects)
  • Humans
  • Injections, Intravenous
  • Intraoperative Period
  • Laryngoscopy
  • Male
  • Microsurgery
  • Middle Aged
  • Practolol (administration & dosage, pharmacology)

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