[Pharmacokinetics of trimethoprim and sulfametrol in patients with end stage renal failure and hemodialysis treatment (author's transl)].

Abstract

In 6 patients with regular dialysis treatment the pharmacokinetics of intravenously administered trimethoprim and sulfametrol were investigated not only during dialysis procedure but also during the dialysis-free interval. Half-life of the free plasma sulfametrol component is normal even in cases with absent renal function and can be markedly reduced by hemodialysis treatment. The N4-acetylated main metabolite of the sulfonamide is - similar to trimethoprim - hardly dialyzable. Half-life of the latter drug component is prolonged in patients with far advanced renal failure. Due to the excellent dialysanceof the free plasma sulfonamide component the elimination of total sulfametrol is normal during hemodialysis despite cumulation of the N4-acetylated metabolite. Because of the tendency of this metabolite to cumulation, in dialysis patients the compound preparation of trimethoprim and sulfametrol should be used only for trasient treatment of acute infections.

• Authors: P Schmidt, A Korn, G Hitzenberger, J Zazgornik, H Kopsa, P Pils
• Journal: Wiener medizinische Wochenschrift (1946) (Wien Med Wochenschr) Vol. 130 Issue 4 Pg. 171-3 (Feb 29 1980) ISSN: 0043-5341 [Print] Austria
• Vernacular Title: Pharmakokinetik von Trimethoprim und Sulfametrol bei Patienten mit terminaler Niereninsuffzienx und Hämodialysebehandlung.
• PMID: 7376686 (Publication Type: English Abstract, Journal Article)

Chemical References

• Drug Combinations
• Sulfonamides
• Trimethoprim

Topics

• Adult
• Aged
• Drug Combinations
• Female
• Half-Life
• Humans
• Kidney Failure, Chronic (drug therapy)
• Male
• Middle Aged
• Renal Dialysis
• Sulfonamides (metabolism, therapeutic use)
• Trimethoprim (metabolism, therapeutic use)