Experiments in mice and rats on the induction of joint lesions following injections of serum and in chronic virus infection.

Abstract

Rats and mice, in contrast to rabbits, appeared to be insusceptible to the development of rheumatoid-like joint lesions on repeated injections with bovine serum--the serum sickness model. Persistent infection of mice with the lactic dehydrogenase virus likewise failed to induce joint lesions.

• Authors: G Oldham, A R Poole, J M Brownson, B W Mahy, R R Coombs
• Journal: International archives of allergy and applied immunology (Int Arch Allergy Appl Immunol) Vol. 62 Issue 2 Pg. 213-20 ( 1980) ISSN: 0020-5915 [Print] Switzerland
• PMID: 7372367 (Publication Type: Journal Article)

Topics

• Animals
• Blood
• Cattle
• Female
• Hemagglutination Tests
• Joint Diseases (pathology)
• Kidney (pathology)
• Lactate dehydrogenase-elevating virus
• Male
• Mice
• Mice, Inbred A
• Mice, Inbred BALB C
• Mice, Inbred C3H
• Mice, Inbred CBA
• Mice, Inbred DBA
• Mice, Nude
• Rabbits
• Rats
• Serum Sickness (etiology)