[Comparative study in nuclear and cytoplasmic RNA species of mouse liver, Guelstein ascites hepatoma 22A and liver of tumor-bearing animals].

Abstract

A comparative study on nuclear and cytoplasmic DNA-like RNA species from normal liver, malignant Guelstein hepatoma 22A and liver of tumor-bearing animals was carried out. The nuclear RNA's were found to be poorly and rapidly labelling, the latter comprising a lesser proportion in hepatoma as compared with a normal liver. The comparison of labelling rates of nuclear and cytoplasmic RNA species shows that the nucleus-to-cytoplasme RNA transport is accelerated in hepatoma. Besides, cytoplasmic DNA-like RNA's are more heterogeneous in hepatoma and liver of tumor-bearing animals than in normal liver cells.

• Authors: I B Zborovskaia, R P Alekhina, A B Likhtenshteĭn, V S Shapot
• Journal: Biokhimiia (Moscow, Russia) (Biokhimiia) Vol. 43 Issue 8 Pg. 1516-24 (Aug 1978) ISSN: 0320-9725 [Print] Russia (Federation)
• Vernacular Title: Sravnitel'noe issledovanie iadernykh i tsitoplazmaticheskikh RNK kletok normal'noĭ pecheni myshi, gepatomy 22A gel'shteĭn i pecheni zhivotnogo-opukholenositelia.
• PMID: 737233 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• RNA, Neoplasm
• RNA

Topics

• Animals
• Biological Transport
• Cell Nucleus (metabolism)
• Cytoplasm (metabolism)
• Kinetics
• Liver (metabolism)
• Liver Neoplasms, Experimental (metabolism)
• Mice
• RNA (metabolism)
• RNA, Neoplasm (metabolism)