| Abstract | The effect of ambient temperature (Ta) on the rectal temperature (Tre) response to intraventricular injection of bombesin has been evaluated in conscious adult male rats. At Ta = 4 degrees C, bombesin (50 ng-1 microgram) caused a marked hypothermia which was dose-dependent both in terms of the magnitude and of the duration of the response. The bombesin-induced hypothermia was reduced at Ta = 24 degrees C, whereas at Ta = 31 or 33 degrees C, the peptide (1 microgram) failed to affect Tre.AtTa = 36 degrees C, bombesin 1-10 micrograms induced an elevation in Tre. The hyperthermia observed at high Ta could be reversed to hypothermia by transferring rats to cold. The analogs [d-Trp8]bombesin or [d-Leu13]bombesin, tested under the same conditions, failed to produce significant changes in Tre. These findings demonstrate that bombesin appears to act in the brain as a poikilothermic agent by disrupting thermoregulation at temperatures below or above thermoneutrality. |
| Authors | Y Taché, Q Pittman, M Brown |
| Journal | Brain research
(Brain Res)
Vol. 188
Issue 2
Pg. 525-30
(Apr 28 1980)
ISSN: 0006-8993 NETHERLANDS |
| PMID | 7370772
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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| Chemical References |
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| Topics |
- Animals
- Body Temperature
(drug effects)
- Body Temperature Regulation
(drug effects)
- Bombesin
(analogs & derivatives, pharmacology)
- Male
- Peptides
(pharmacology)
- Rats
|
