Clinical study of cefuroxime in the treatment of lower respiratory tract infections.

Abstract

Twenty-three hospital in-patients with severe lower respiratory tract infections were treated with cefuroxime sodium. The drug was given intramuscularly in a dose of either 750 mg or 1000 mg at 8-hourly intervals for 5 days. Of the 21 patients who could be assessed, the response to treatment was highly satisfactory and there were no treatment failures. Eight patients had failed to respond to a course of oral antibiotics before being seen. Most of the patients were elderly and all were very ill. The sputum became mucoid in all but 1 patient. There was no change in tests of liver or renal function. Cefuroxime appears to be an effective and well-tolerated drug for the treatment of patients with severe chest infections.

• Authors: T C Samanta, R P Bax, R M Pearson, C W Havard, W Brumfitt, J M Hamilton-Miller
• Journal: Current medical research and opinion (Curr Med Res Opin) Vol. 6 Issue 7 Pg. 466-71 ( 1980) ISSN: 0300-7995 [Print] England
• PMID: 7363646 (Publication Type: Journal Article)

Chemical References

• Cephalosporins
• Cefuroxime

Topics

• Adult
• Aged
• Cefuroxime (administration & dosage, metabolism, therapeutic use)
• Cephalosporins (therapeutic use)
• Female
• Humans
• Injections, Intramuscular
• Male
• Middle Aged
• Respiratory Tract Infections (blood, drug therapy, metabolism)
• Sputum (metabolism)