Effect of FPL57787 in exercise-induced asthma.

Abstract

In ten patients with extrinsic asthma the effects of a new oral chromone FPL57787 and placebo were studied in a random double-blind fashion to assess the effect of FPL57787 in preventing exercise-induced asthma (EIA). Exercise testing consisted of steady state running on an inclined treadmill for up to 8 min. FPL57787 gave significant protection (P less 0.01) compared to placebo from the maximum percentage fall in FEV1, FVC and MMEF after exercise. FPL57787 also produced a small but significant (P less than 0.01) percentage increase in FEV1 2 hr after the drug compared to placebo, whereas no significant increase was seen in FVC or in MMEF.

• Authors: N C Thomson, A G Green, J W Kerr
• Journal: Clinical allergy (Clin Allergy) Vol. 10 Issue 1 Pg. 43-6 (Jan 1980) ISSN: 0009-9090 [Print] England
• PMID: 7363445 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Chromones
• Placebos
• proxicromil

Topics

• Administration, Oral
• Adolescent
• Adult
• Asthma (drug therapy)
• Asthma, Exercise-Induced (drug therapy)
• Chromones (administration & dosage, therapeutic use)
• Double-Blind Method
• Forced Expiratory Volume
• Humans
• Maximal Midexpiratory Flow Rate
• Placebos
• Time Factors
• Vital Capacity