Body composition during long-term treatment of uremia with amino acid supplemented low-protein diet.

Abstract

The influence on body composition of prolonged treatment with low-protein diet (20 g/day) supplemented with the essential amino acids and histidine was studied in 49 patients with chronic renal failure and uremic symptoms. Total body potassium (TBK) was measured with 40K in a whole-body counter. Total body water was determined with dilution of tritiated water. Predicted values for TBK and total body water were obtained from a reference population of 476 healthy subjects. In 38 patients investigated before treatment body weight was normal while mean TBK was 91% of predicted in men and 100% in women. Mean total body water was 104% of predicted in both men and women. Thirty-one patients were investigated at 3-month intervals during treatment for up to 12 months. No significant changes in mean body weight, TBK, or total body water were found. However, in 10/13 patients TBK decreased significantly, presumably due to increased catabolism in connection with intercurrent disease or insufficient energy intake. In the absence of complications long-term treatment with a low-protein diet and essential amino acids in renal failure seems to maintain body cell mass reflected in unchanged TBK.

• Authors: P O Attman, J Ewald, B Isaksson
• Journal: The American journal of clinical nutrition (Am J Clin Nutr) Vol. 33 Issue 4 Pg. 801-10 (Apr 1980) ISSN: 0002-9165 [Print] United States
• PMID: 7361698 (Publication Type: Journal Article)

Chemical References

• Amino Acids, Essential
• Dietary Proteins
• Urea
• Creatinine
• Potassium

Topics

• Adolescent
• Adult
• Amino Acids, Essential (therapeutic use)
• Body Composition
• Body Height
• Body Water (metabolism)
• Body Weight
• Creatinine (blood)
• Dietary Proteins (administration & dosage)
• Female
• Humans
• Kidney Failure, Chronic (diet therapy, metabolism)
• Male
• Middle Aged
• Potassium (metabolism)
• Urea (blood)
• Uremia (metabolism)