HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Therapeutic activity of pretazettine on Rauscher leukemia: comparison with the related Amaryllidaceae alkaloids.

Abstract
Comparative studies on the cytotoxicity and antileukemic activity of limited numbers of Amaryllidaceae alkaloids with pretazettine, a narcissus alkaloid, have been performed on the systems of Rauscher virus-carrier cells and the leukemic mice. Only precriwelline, a stereochemical epimer of pretazettine, has been found to be therapeutically active as that of pretazettine. The natural precursors such as haemanthamine, crinamine and 6-hydroxycrinamide were also moderately active, but the artificial final product, tazettine, was confirmed to be inert. The structure-activity relationship of pretazettine or precriwelline has been partially analyzed. Also, the predominancy of antiviral activity relative to cytotoxicity of the alkaloids has been demonstrated when compared with some standard antileukemic drugs.
AuthorsE Furusawa, H Irie, D Combs, W C Wildman
JournalChemotherapy (Chemotherapy) Vol. 26 Issue 1 Pg. 36-45 ( 1980) ISSN: 0009-3157 [Print] Switzerland
PMID7353439 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Alkaloids
  • Amaryllidaceae Alkaloids
  • Antineoplastic Agents
  • pretazettine
Topics
  • Alkaloids (pharmacology, therapeutic use)
  • Amaryllidaceae Alkaloids
  • Animals
  • Antineoplastic Agents (pharmacology)
  • Cell Line
  • Leukemia, Experimental (drug therapy, mortality)
  • Mice
  • Rauscher Virus (drug effects, growth & development)
  • Structure-Activity Relationship
  • Time Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: