Contact urticaria from cinnamic aldehyde.

Abstract	Lip swelling developed following the use of a cinnamic aldehyde-containing mouthwash in a woman with allergic rhinitis and asthma. Open application of the mouthwash on the antecubital fossae of the patient and control subjects produced immediate erythematous or urticarial responses in all tested individuals. Subsequent investigation established cinnamic aldehyde as the responsible ingredient. The incidence of positive reactions was shown to depend on site of application, vehicle, concentration, and time of reading. Of several related cinnamates, only cinnamic acid produced easily detectable responses at similar concentrations.
Authors	C G Mathias, R R Chappler, H I Maibach
Journal	Archives of dermatology (Arch Dermatol) Vol. 116 Issue 1 Pg. 74-6 (Jan 1980) ISSN: 0003-987X [Print] United States
PMID	7352767 (Publication Type: Case Reports, Journal Article)
Chemical References	Aldehydes Mouthwashes Pharmaceutical Vehicles Acrolein cinnamaldehyde
Topics	Acrolein (adverse effects, analogs & derivatives) Adult Aldehydes (adverse effects) Female Humans Lip Mouthwashes (adverse effects) Patch Tests Pharmaceutical Vehicles Time Factors Urticaria (chemically induced)

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