The acceptance of a vitreous carbon alloplastic material, Proplast, in the rabbit eye.

Abstract

Proplast, a vitreous, carbon-Teflon, fluorocarbon polymer, was tested in rabbits for corneal tolerance and acceptance. Toxicity, vascularization, epithelialization, infection, and extrusion were studied clinically and histologically. Four techniques were used: implantation of irregular-shaped pieces of material in an interlamellar corneal pocket, lamellar graft implantation with one exposed surface, full-thickness corneal implants in a manner similar to penetrating keratoplasty, and full-thickness implants covered by a conjunctival flap. Results showed that Proplast allows fibrovascular ingrowth and stabilization without a significant foreign body response or encapsulation for a period of observation from 6 weeks to 4 months. Evidence of epithelial coverage and epithelial ingrowth was also found. Coverage of the Proplast with conjunctiva or corneal tissue was essential to prevent extrusion and infection.

• Authors: J C Barber, F Feaster, D Priour
• Journal: Investigative ophthalmology & visual science (Invest Ophthalmol Vis Sci) Vol. 19 Issue 2 Pg. 182-91 (Feb 1980) ISSN: 0146-0404 [Print] United States
• PMID: 7351352 (Publication Type: Journal Article)

Chemical References

• Proplast
• Polytetrafluoroethylene

Topics

• Animals
• Conjunctiva (surgery)
• Cornea (pathology, surgery)
• Polytetrafluoroethylene (adverse effects)
• Proplast (adverse effects)
• Prostheses and Implants
• Prosthesis Design
• Rabbits