Estrogen receptor protein in malignant carcinoid tumor: a report of 2 cases.

Abstract

Two cases of metastatic malignant carcinoid tumor in elderly women contained significant amounts of estrogen receptor (19 and 32 femtomoles/mg protein) as shown by Scatchard-plot analysis of a dextran-coated charcoal assay, inhibition of binding by an estrogen analog (67 and 63%) and high-affinity binding (Kd = 6.8 and 2.6 x 10(-10) M). The demonstration of estrogen receptor in malignant carcinoid tumor expands the spectrum of non-breast or non-gynecologic neoplasms that contain the receptor. The significane of estrogen receptor in such tumors is uncertain; it may represent aberrant derepression of the gene for estrogen receptor protein in a malignant tumor.

• Authors: A A Keshgegian, J E Wheeler
• Journal: Cancer (Cancer) Vol. 45 Issue 2 Pg. 293-6 (Jan 15 1980) ISSN: 0008-543X [Print] United States
• PMID: 7351012 (Publication Type: Case Reports, Journal Article)

Chemical References

• Receptors, Estrogen
• Estradiol

Topics

• Aged
• Carcinoid Tumor (metabolism, pathology, secondary)
• Estradiol (metabolism)
• Female
• Humans
• Ileal Neoplasms (metabolism)
• Liver Neoplasms (metabolism)
• Neoplasms, Hormone-Dependent (metabolism)
• Receptors, Estrogen (genetics, metabolism)
• Suppression, Genetic