Doridosine: a new hypotensive N-methylpurine riboside from the nudibranch Anisodoris nobilis.

Abstract	A new N-methylpurine riboside (doridosine), probably N1-Methylisoguanosine, was isolated from the digestive glands of a nudibranch. Doridosine produces prolonged hypotension and bradycardia in anesthetized rats, decreases the rate and the amplitude of contraction of guinea pig atria in vitro, and causes the heart rate in anesthetized mice to be reduced by 50 percent for many hours after which the animals recover completely.
Authors	F A Fuhrman, G J Fuhrman, Y H Kim, L A Pavelka, H S Mosher
Journal	Science (New York, N.Y.) (Science) Vol. 207 Issue 4427 Pg. 193-5 (Jan 11 1980) ISSN: 0036-8075 [Print] United States
PMID	7350655 (Publication Type: Journal Article)
Chemical References	Antihypertensive Agents Guanosine doridosine
Topics	Animals Antihypertensive Agents (isolation & purification) Guanosine (analogs & derivatives, isolation & purification, pharmacology) Guinea Pigs Heart Rate (drug effects) Mice Mollusca (analysis) Rats

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