Abstract |
Bradikininogen, kallikreinogen, kallikrein, kininase I as well as blood BAEE-esterase and antitryptic activities were studied in development of extensive myocardial infarction in dogs. Some components of kinine system were activated already within 1 hr after ligation of coronary artery, maximal their activation was observed within 3 hrs. In this period content of bradikinin was distinctly decreased--up to 42% of the initial level, kallikrein was activated 8-8-fold, content of kallikreinogen was twice decreased and BAEE esterase activity of blood was increased moderately. Simultaneously, inhibition of kininase I by 30-40% and of antitryptic activity was observed. Gradual normalization of the patterns studied occurred further: kininase I--with 5 days, kallikreinogen, kallikrein and bradikinin--within 10 days of infarction development. Antitryptic activity of blood not only reached normal values but exceeded them within 2 days after the artery ligation. The data obtained suggest the hyperproduction of kinins; the possibility is discussed on the potentiation and prolongation of effect of these physiologically active polypeptides.
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Authors | R A Frol'kis, L M Gunina |
Journal | Voprosy meditsinskoi khimii
(Vopr Med Khim)
1978 Nov-Dec
Vol. 24
Issue 6
Pg. 747-53
ISSN: 0042-8809 [Print] Russia (Federation) |
Vernacular Title | Izmeneniia kallikrein-kininovoĭ sistemy krovi v protsesse razvitia éksperimental'nogo infarkta miokarda. |
PMID | 734974
(Publication Type: Journal Article)
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Chemical References |
- Benzamides
- Kininogens
- Kinins
- Trypsin Inhibitors
- Arginine
- Esterases
- Carboxylic Ester Hydrolases
- benzoylarginine ethyl esterase
- Lysine Carboxypeptidase
- Kallikreins
- Bradykinin
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Topics |
- Animals
- Arginine
- Benzamides
- Bradykinin
(blood)
- Carboxylic Ester Hydrolases
- Dogs
- Esterases
(blood)
- Kallikreins
(blood)
- Kininogens
(blood)
- Kinins
(blood)
- Lysine Carboxypeptidase
(blood)
- Myocardial Infarction
(blood, enzymology)
- Time Factors
- Trypsin Inhibitors
(blood)
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