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[Changes in the kallikrein-kinin system of the blood during development of experimental myocardial infarct].

Abstract
Bradikininogen, kallikreinogen, kallikrein, kininase I as well as blood BAEE-esterase and antitryptic activities were studied in development of extensive myocardial infarction in dogs. Some components of kinine system were activated already within 1 hr after ligation of coronary artery, maximal their activation was observed within 3 hrs. In this period content of bradikinin was distinctly decreased--up to 42% of the initial level, kallikrein was activated 8-8-fold, content of kallikreinogen was twice decreased and BAEE esterase activity of blood was increased moderately. Simultaneously, inhibition of kininase I by 30-40% and of antitryptic activity was observed. Gradual normalization of the patterns studied occurred further: kininase I--with 5 days, kallikreinogen, kallikrein and bradikinin--within 10 days of infarction development. Antitryptic activity of blood not only reached normal values but exceeded them within 2 days after the artery ligation. The data obtained suggest the hyperproduction of kinins; the possibility is discussed on the potentiation and prolongation of effect of these physiologically active polypeptides.
AuthorsR A Frol'kis, L M Gunina
JournalVoprosy meditsinskoi khimii (Vopr Med Khim) 1978 Nov-Dec Vol. 24 Issue 6 Pg. 747-53 ISSN: 0042-8809 [Print] Russia (Federation)
Vernacular TitleIzmeneniia kallikrein-kininovoĭ sistemy krovi v protsesse razvitia éksperimental'nogo infarkta miokarda.
PMID734974 (Publication Type: Journal Article)
Chemical References
  • Benzamides
  • Kininogens
  • Kinins
  • Trypsin Inhibitors
  • Arginine
  • Esterases
  • Carboxylic Ester Hydrolases
  • benzoylarginine ethyl esterase
  • Lysine Carboxypeptidase
  • Kallikreins
  • Bradykinin
Topics
  • Animals
  • Arginine
  • Benzamides
  • Bradykinin (blood)
  • Carboxylic Ester Hydrolases
  • Dogs
  • Esterases (blood)
  • Kallikreins (blood)
  • Kininogens (blood)
  • Kinins (blood)
  • Lysine Carboxypeptidase (blood)
  • Myocardial Infarction (blood, enzymology)
  • Time Factors
  • Trypsin Inhibitors (blood)

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