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Effect of a new bifunctional nitrosoureido derivative on human colorectal tumor xenografts.

Abstract
The tumor inhibiting effect of a newly developed bifunctional nitrosoureido derivative (GYKI-13324) was studied on human colorectal tumor xenograft lines. Given orally in single or multiple daily doses, GYKI-13324 produced long-term or total regression of adenomatous, but only marginal growth delay of mucinous tumors. GYKI-13324, with slightly lower toxicity than that of BCNU, seems to be a candidate in the clinical management of colorectal tumors.
AuthorsL Kopper, K Lapis, E Csányi, T Horváth
JournalAnticancer research (Anticancer Res) Vol. 1 Issue 4 Pg. 229-33 ( 1981) ISSN: 0250-7005 [Print] Greece
PMID7345967 (Publication Type: Journal Article)
Chemical References
  • Antineoplastic Agents
  • Nitrosourea Compounds
  • GYKI 13324
  • Carmustine
Topics
  • Animals
  • Antineoplastic Agents (pharmacology)
  • Carmustine (pharmacology)
  • Cell Division (drug effects)
  • Cell Line
  • Colonic Neoplasms (drug therapy)
  • Humans
  • Mice
  • Mice, Inbred CBA
  • Neoplasm Transplantation
  • Nitrosourea Compounds (pharmacology)
  • Rectal Neoplasms (drug therapy)
  • Transplantation, Heterologous

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