[Effect of pretreatment with radiation-detoxified endotoxin on endotoxin shock in dogs].

Abstract

The protective action of the radiation detoxified endotoxin preparation (Tolerin) on the endotoxin shock of dogs was studied. Endotoxin shock was induced by the intravenous administration of 2 mg/kg of Escherichia coli endotoxin. It was found that the intraperitoneal administration of 4 mg of radiation-detoxified endotoxin (Tolerin) 48 hours prior to the inducement of shock prevents the drop in blood pressure and the decrease of cardiac output which promptly appear in the acute phase of endotoxin shock.

• Authors: A Balogh, L Bertók, S Juhász-Nagy
• Journal: Acta chirurgica Academiae Scientiarum Hungaricae (Acta Chir Acad Sci Hung) Vol. 22 Issue 1-2 Pg. 23-9 ( 1981) ISSN: 0001-5431 [Print] Hungary
• Vernacular Title: Wirkung der Vorbehandlung mit strahlendetoxifiziertem Endotoxin auf den Endotoxinschock bei Hunden.
• PMID: 7345834 (Publication Type: English Abstract, Journal Article)

Chemical References

• Endotoxins
• tolerin

Topics

• Animals
• Blood Pressure (drug effects)
• Cardiac Output (drug effects)
• Dogs
• Endotoxins (pharmacology, radiation effects, therapeutic use)
• Female
• Male
• Premedication
• Shock, Septic (drug therapy, prevention & control)