Molecular mechanisms of inflammation.

Abstract

Among a vast number of chemical mediators of inflammation such as histamine, 5-hydroxytryptamine, bradykinin, SRS-A the metabolites of arachidonic acid (AA) attracted vivid attention in the last ten years. Aspirin-like drugs are inhibitors of AA cyclo-oxygenation, while anti-inflammatory steroids inhibit the liberation of AA from phospholipids. These biochemical effects of steroidal and non-steroidal anti-inflammatory drugs lead to a suppression of generation of primary prostaglandins (e.g. PGE2) and therefore the curative action of these drugs has been explained in terms of depletion of pro-inflammatory prostaglandins. Recently, Samuelsson et al. described a new class of AA metabolites--leukotriens. Leukotrien C, which derives from 5-hydroperoxyeicosatetranoic acid and cysteine, is supposed to be SRS-A. The discovery of Samuelsson revived a known idea, that any biochemical transformation of AA (including the cyclo-oxygenase pathway) is initiated by its lipoxydation. Thus formed highly active hydroperoxy fatty acids and deriving oxygen-centred free radicals are important not only for a further biochemical transformation of AA, but also because of their biological action per se. In this respect Kuehl et al. proposed the most interesting idea that a true mediator of inflammation is PGG2 owing to the presence of 15-hydroperoxy group in its molecule, and its capability to generate either TXA2 or free hydroxy radical. It may well be that primary prostaglandins play a secondary role in inflammation, whereas unstable metabolites of AA are the real mediators of inflammation, owing to generation of either destructive free radicals or non-prostaglandin pro-inflammatory mediators (e.g. thromboxane A2, leukotrien C, prostacyclin).

• Authors: R J Gryglewski
• Journal: European journal of rheumatology and inflammation (Eur J Rheumatol Inflamm) Vol. 4 Issue 2 Pg. 153-9 ( 1981) ISSN: 0140-1610 [Print] England
• PMID: 7343317 (Publication Type: Journal Article)

Chemical References

• Arachidonic Acids
• Free Radicals
• Prostaglandins

Topics

• Arachidonic Acids (metabolism)
• Biotransformation
• Free Radicals
• Humans
• Inflammation (etiology)
• Oxidation-Reduction
• Prostaglandins (metabolism)