[Clinical experience with cefroxadine in bacterial infection of children (author's transl)].

Abstract

In order to evaluate effectiveness of cefroxadine (CXD) in the treatment of bacterial infections of children, the clinical studies were carried out. CXD was orally administered to 30 patients at daily dose of 27.5 approximately 50.0 mg/kg (average 32.3 mg/kg) in 3 approximately 4 divided dose for 3 approximately 10 days (average 4.9 days). The overall efficacy rate in 30 cases was 93.3%, i.e., excellent 22 (73.3%), good in 6 (20.0%), fair in 1 (3.3%) and poor in 1 case (3.3%). Drug eruption and transient eosinophilia were observed in 1 case each out of 30 cases (6.7%), but any other abnormality was not observed throughout this series. Based on the above results, CXD was thus considered to be a useful antibiotic in treatment of pediatric infections.

• Authors: T Sekiguchi, T Hosoda, T Ichioka, M Miyao, T Kokawa, Y Uyama, H Tanaka
• Journal: The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 34 Issue 12 Pg. 1691-6 (Dec 1981) ISSN: 0368-2781 [Print] Japan
• PMID: 7334593 (Publication Type: Journal Article)

Chemical References

• Cephalosporins
• cefroxadine
• Cephradine

Topics

• Bacterial Infections (drug therapy, microbiology)
• Cephalosporins (therapeutic use)
• Cephradine (administration & dosage, adverse effects, analogs & derivatives, therapeutic use)
• Child
• Child, Preschool
• Drug Evaluation
• Female
• Humans
• Infant
• Male