Chronic granulomatous disease: effect of sulfamethoxazole/trimethoprim on neutrophil microbicidal function.

Abstract	Normal and chronic granulomatous disease (CGD) neutrophils accumulated sulfamethoxazole (SMX) 3-fold and trimethoprim (TMP) 14-fold, possibly through a non-ionic diffusion and pH-partition mechanism. CGD neutrophils incubated with SMX/TMP after phagocytosis of S. aureus killed the bacteria. These findings explain the clinically observed beneficial effect of SMX/TMP in the treatment of infections in CGD and in other conditions characterized by impaired phagocyte microbicidal capacity.
Authors	R A Seger, S Baumgartner, L X Tiefenauer, F K Gmünder
Journal	Helvetica paediatrica acta (Helv Paediatr Acta) Vol. 36 Issue 6 Pg. 579-88 ( 1981) ISSN: 0018-022X [Print] Switzerland
PMID	7333866 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Trimethoprim Sulfamethoxazole
Topics	Drug Therapy, Combination Granulomatous Disease, Chronic (drug therapy) Humans Neutrophils (drug effects) Phagocytosis (drug effects) Sulfamethoxazole (pharmacology, therapeutic use) Trimethoprim (pharmacology, therapeutic use)

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