Abstract |
Normal and chronic granulomatous disease (CGD) neutrophils accumulated sulfamethoxazole (SMX) 3-fold and trimethoprim ( TMP) 14-fold, possibly through a non-ionic diffusion and pH-partition mechanism. CGD neutrophils incubated with SMX/ TMP after phagocytosis of S. aureus killed the bacteria. These findings explain the clinically observed beneficial effect of SMX/ TMP in the treatment of infections in CGD and in other conditions characterized by impaired phagocyte microbicidal capacity.
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Authors | R A Seger, S Baumgartner, L X Tiefenauer, F K Gmünder |
Journal | Helvetica paediatrica acta
(Helv Paediatr Acta)
Vol. 36
Issue 6
Pg. 579-88
( 1981)
ISSN: 0018-022X [Print] Switzerland |
PMID | 7333866
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Trimethoprim
- Sulfamethoxazole
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Topics |
- Drug Therapy, Combination
- Granulomatous Disease, Chronic
(drug therapy)
- Humans
- Neutrophils
(drug effects)
- Phagocytosis
(drug effects)
- Sulfamethoxazole
(pharmacology, therapeutic use)
- Trimethoprim
(pharmacology, therapeutic use)
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