Abstract |
Both myxoma and fibroma viruses were found to be sensitive in vitro to the effects of phosphonoacetic acid. Detectable myxoma virus replication was inhibited at a drug concentration of 100 micrograms/ml. Fibroma virus replication was inhibited at a concentration of 500 micrograms/ml. Because of this difference in sensitivity, myxoma virus was used to infect rabbits to test that efficacy of phosphonoacetic acid in the treatment of a systemic viral disease. Rabbits were given 400 mg kg-1 day-1 of phosphonoacetic acid subcutaneously in two injections. Phosphonoacetic acid-treated animals showed a reduction in the severity of disease. Neither serum viral antigen nor infectious virus could be detected. In phosphate buffered saline-treated animals both serum viral antigen and infectious virus were found. All animals treated with phosphate buffered saline died of myxomatosis.
|
Authors | J M Goodrich, K W Lee, H C Hinze |
Journal | Archives of virology
(Arch Virol)
Vol. 70
Issue 2
Pg. 157-64
( 1981)
ISSN: 0304-8608 [Print] Austria |
PMID | 7332492
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
|
Chemical References |
- Antibodies, Viral
- Antiviral Agents
- Organophosphorus Compounds
- Phosphonoacetic Acid
|
Topics |
- Animals
- Antibodies, Viral
(analysis)
- Antiviral Agents
- Myxoma virus
(drug effects, immunology)
- Myxomatosis, Infectious
(drug therapy)
- Organophosphorus Compounds
(pharmacology)
- Phosphonoacetic Acid
(pharmacology, therapeutic use)
- Rabbits
- Viral Plaque Assay
- Virus Replication
(drug effects)
|