Comparative study on the nuclear DNA content of leiomyoma, leiomyoblastoma and leiomyosarcoma of the stomach and small intestine.

Abstract

The nuclear DNA content of tumor cells in 5 leiomyomas, 4 leiomyoblastomas and 2 leiomyosarcomas of the stomach and 1 leiomyosarcoma of the small intestine was examined. From the viewpoint of nuclear DNA content, leiomyoblastoma was between leiomyoma and leiomyosarcoma. A definite difference in nuclear DNA content exists among leiomyoma, leiomyoblastoma and leiomyosarcoma, and percentage of nuclei with a DNA content of 3 times or 4 times over the basic chromosome content represented good indices for distinguishing between benign and malignant conditions. A diagnosis of leiomyocarcinoma may be more accurate when over 80% of the nuclei have DNA content values over 3 times of basic nuclear DNA content and when over 50% exhibit more than 4 times of basic content.

• Authors: O Kimura, N Kaibara, H Tamura, H Nishidoi, T Okamoto, S Koga
• Journal: The Japanese journal of surgery (Jpn J Surg) Vol. 11 Issue 6 Pg. 428-32 ( 1981) ISSN: 0047-1909 [Print] Japan
• PMID: 7328935 (Publication Type: Comparative Study, Journal Article)

Chemical References

• DNA, Neoplasm

Topics

• Adult
• Aged
• DNA, Neoplasm (analysis)
• Diagnosis, Differential
• Female
• Humans
• Intestinal Neoplasms (analysis, diagnosis)
• Intestine, Small
• Leiomyoma (analysis, diagnosis)
• Leiomyosarcoma (analysis, diagnosis)
• Male
• Middle Aged
• Stomach Neoplasms (analysis, diagnosis)