Studies of the tumorigenic potential of 4-substituted phenylhydrazines by the subcutaneous route.

Abstract

4-Methylphenylhydrazine hydrochloride (4-MPH) was administered to randomly bred Swiss mice as 26 weekly sc injections of 140 microgram per gram of body weight and N'-acetyl-4-(hydroxymethyl)phenylhydrazine (AMPH) as 26 weekly sc injections of 500 microgram/g. As a solvent control, physiological saline was also given as 26 weekly sc injections of 0.01 ml/g. The 4-MPH treatment induced a significant incidence (24%) of fibrosarcomas in males. In the 4-MPH-treated females and some AMPH-treated male mice, a few soft-tissue tumors were observed; however, their appearance could not be related to treatment. 4-MPH is formed under special experimental conditions from 4-hydroxymethylphenyl-hydrazine, which is an in vitro breakdown product of agaritine, an ingredient of the cultivated mushroom Agaricus bisporus. The implications of the findings are discussed.

• Authors: B Toth, D Nagel
• Journal: Journal of toxicology and environmental health (J Toxicol Environ Health) 1981 Jul-Aug Vol. 8 Issue 1-2 Pg. 1-9 ISSN: 0098-4108 [Print] United States
• PMID: 7328695 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Phenylhydrazines
• 4-methylphenylhydrazine
• N'-acetyl-N'-(4-hydroxymethyl)phenylhydrazine

Topics

• Animals
• Female
• Fibrosarcoma (chemically induced)
• Male
• Mice
• Neoplasms, Experimental (chemically induced)
• Phenylhydrazines (toxicity)
• Soft Tissue Neoplasms (chemically induced)