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Paracetamol, tiaramide and placebo for pain relief after orthopedic surgery.

Abstract
Eighty patients took part in this double-blind, single-dose group-comparative study, comparing the analgesic efficacy of tiaramide hydrochloride 100 mg and 200 mg, paracetamol 1000 mg, and placebo for pain after orthopedic operations. The four treatment groups were similar on entry to the trial. Pain relief was assessed up to 6 h after treatment, using a visual analogue pain scale and a pain score, both giving similar results. Statistically significant pain relief (mean pain intensity differences and sum of pain intensity differences) was seen in the group receiving paracetamol compared to those receiving placebo or tiaramide from 1 h to 6 h after drug ingestion. There was no significant difference between placebo and tiaramide 100 or 200 mg. No adverse reactions were reported.
AuthorsB Winnem, B Samstad, H Breivik
JournalActa anaesthesiologica Scandinavica (Acta Anaesthesiol Scand) Vol. 25 Issue 3 Pg. 209-14 (Jun 1981) ISSN: 0001-5172 [Print] England
PMID7324837 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Analgesics
  • Benzothiazoles
  • Piperazines
  • Thiazoles
  • Acetaminophen
  • tiaramide
Topics
  • Acetaminophen (therapeutic use)
  • Adolescent
  • Adult
  • Analgesics (therapeutic use)
  • Benzothiazoles
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Middle Aged
  • Orthopedics
  • Pain, Postoperative (drug therapy)
  • Piperazines (therapeutic use)
  • Random Allocation
  • Thiazoles (therapeutic use)
  • Time Factors

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