Potential antitumor agents. XVII. physalin B and 25,26-epidihydrophysalin C from Witheringia coccoloboides.

Abstract

An investigation of Witheringia coccoloboides (Dammer) A. T. Hunziker [Capsicum fuscoviolaceum (Cufodontis) Mort. And Standl.] roots has resulted in the isolation of two cytotoxic compounds: physalin B (1) and a novel physalin, which was characterized by spectral analysis as 25,26-epidihydrophysalin C (2). Both compounds have demonstrated cytotoxic activity in 9KB and 9PS tumor cells (in vitro). Physalin B (1) has demonstrated moderate activity against the 3PS mouse leukemia (in vivo).

• Authors: M D Antoun, D Abramson, R L Tyson, C J Chang, J L McLaughlin, G Peck, J M Cassady
• Journal: Journal of natural products (J Nat Prod) 1981 Sep-Oct Vol. 44 Issue 5 Pg. 579-85 ISSN: 0163-3864 [Print] United States
• PMID: 7320739 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antineoplastic Agents, Phytogenic
• Lactones
• Secosteroids
• Steroids
• physalin B
• 25,26-epidihydrophysalin C

Topics

• Animals
• Antineoplastic Agents, Phytogenic (isolation & purification, pharmacology)
• Chemical Phenomena
• Chemistry
• Humans
• In Vitro Techniques
• Lactones (isolation & purification, pharmacology)
• Neoplasms, Experimental (drug therapy)
• Plants, Medicinal (analysis)
• Secosteroids
• Steroids