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Fredericamycin A, a new antitumor antibiotic. II. Biological properties.

Abstract
Fredericamycin A is a novel antibiotic produced by a soil isolate of Streptomyces griseus (FCRC-48). In vitro, fredericamycin A exhibits antibacterial, antifungal, and cytotoxic activities. In vivo, fredericamycin A exhibits very good antitumor activity against P388 mouse leukemia as well as the CD8F mammary tumor and marginal activity against B16 melanoma. Fredericamycin A failed to demonstrate any interaction with DNA and inhibited protein and RNA synthesis preferentially to DNA synthesis in Bacillus subtilis and P388 cells.
AuthorsD J Warnick-Pickle, K M Byrne, R C Pandey, R J White
JournalThe Journal of antibiotics (J Antibiot (Tokyo)) Vol. 34 Issue 11 Pg. 1402-7 (Nov 1981) ISSN: 0021-8820 [Print] England
PMID7319903 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Antibiotics, Antineoplastic
  • Isoquinolines
  • Mutagens
  • Spiro Compounds
  • DNA
  • fredericamycin A
Topics
  • Animals
  • Antibiotics, Antineoplastic (pharmacology)
  • Bacteria (drug effects)
  • Chemical Phenomena
  • Chemistry
  • DNA (metabolism)
  • Isoquinolines (pharmacology)
  • Mice
  • Microbial Sensitivity Tests
  • Mutagens
  • Neoplasms, Experimental (drug therapy)
  • Spiro Compounds (pharmacology)

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