Subchronic administration of caffeine and theophylline in drinking water: effects on rat liver RNA polymerase I activity.

Abstract

Administration of caffeine or theophylline, 0.2 mg/ml (an average of 20 mg/kg/d) of drinking water, to male CD rats, 2 months of age, over a 15 week period resulted in the elevation of liver RNA polymerase I activity by 2-3 fold as assayed in isolated nuclei. This increase in activity was already apparent by the fourth week of exposure. The changes in RNA polymerase I activity were accompanied by moderate liver hypertrophy.

• Authors: P Shields, K McCarty, P F Dimond, S S Elridi, J A Todhunter
• Journal: Drug and chemical toxicology (Drug Chem Toxicol) Vol. 4 Issue 2 Pg. 89-100 ( 1981) ISSN: 0148-0545 [Print] United States
• PMID: 7318687 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Caffeine
• Theophylline
• DNA-Directed RNA Polymerases
• RNA Polymerase I

Topics

• Animals
• Caffeine (toxicity)
• DNA-Directed RNA Polymerases (analysis)
• Drinking (drug effects)
• Hypertrophy
• Liver (drug effects, enzymology, pathology)
• Male
• RNA Polymerase I (analysis)
• Rats
• Rats, Inbred Strains
• Theophylline (toxicity)