HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Reduction of myocardial infarct size by the calcium antagonist fr 7534.

Abstract
This study was conducted to determine the effect of FR 7534, a light-stable derivative of nifedipine on hemodynamics, coronary collateral blood flow and myocardial infarct size in the anesthetized dog. Myocardial infarction was produced by a 2-hour occlusion and reperfusion of the distal third of the left anterior descending coronary artery in control dogs, FR 7534-treated dogs and FR 7534-treated dogs with a constant aortic blood pressure. FR 7534 alone produced significant decreases in heart rate and mean aortic blood pressure, however, no change in collateral blood flow of central ischemic zones was observed. On the other hand, when aortic blood pressure was held constant, FR 7534 produced a significant increase in coronary collateral blood flow. With or without a constant aortic perfusion pressure, FR 7534 significantly reduced infarct size as compared to control experiments (33.5 to 4.3 and 7.5% of the area at risk infarcted, respectively). The present results demonstrate the efficacy of a new calcium antagonist, FR 7534, to protect ischemic myocardium with or without a change in oxygen supply via the coronary collateral circulation.
AuthorsC M Meils, G J Gross, H L Brooks, D C Warltier
JournalCardiology (Cardiology) Vol. 68 Issue 3 Pg. 146-60 ( 1981) ISSN: 0008-6312 [Print] Switzerland
PMID7317884 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Pyridines
  • FR 7534
  • Nifedipine
Topics
  • Animals
  • Blood Pressure (drug effects)
  • Collateral Circulation (drug effects)
  • Coronary Circulation (drug effects)
  • Dogs
  • Heart Rate (drug effects)
  • Myocardial Infarction (drug therapy)
  • Nifedipine (analogs & derivatives, pharmacology)
  • Pyridines (pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: