Prolactin and contact sensitivity.

Abstract	Hypophysectomized (Hypo-X) rats did not develop contact dermatitis in response to dinitrochlorobenzene (DNCB). Syngeneic pituitary grafts placed under the kidney capsule or daily treatment with prolactin restored the DNCB-reactivity of Hypo-X animals. Combined treatment with other pituitary hormones was ineffective. Treatment of normal rats with a potent prolactin antagonist drug, bromocriptine, was as effective in inhibiting contact sensitivity as was hypophysectomy. These results indicate the contact sensitivity is a prolactin dependent reaction.
Authors	E Nagy, I Berczi
Journal	Allergy (Allergy) Vol. 36 Issue 6 Pg. 429-31 (Aug 1981) ISSN: 0105-4538 [Print] Denmark
PMID	7316110 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Dinitrochlorobenzene Bromocriptine Prolactin
Topics	Animals Bromocriptine (therapeutic use) Cattle Dermatitis, Contact (etiology) Dinitrochlorobenzene Female Humans Hypophysectomy Pituitary Gland (transplantation) Prolactin (metabolism, pharmacology) Rats Rats, Inbred F344

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