Effect of tinofedrine (Homburg D8955) on cerebral blood flow in multi-infarct dementia.

Abstract

Tinofedrine, a new derivative of l-norephedrine, was examined for cerebral vasodilator activity in man. Ten patients with reduced cerebral blood flow (CBF) and multi-infarct dementia were given the drug intravenously. Cerebral blood flow increased significantly by 28% from a mean of 43.3 to 55.5 ml/100 g/min.

• Authors: J Merory, G H Du Boulay, J Marshall, J Morris, R W Russell, L Symon, D J Thomas
• Journal: Journal of neurology, neurosurgery, and psychiatry (J Neurol Neurosurg Psychiatry) Vol. 41 Issue 10 Pg. 900-2 (Oct 1978) ISSN: 0022-3050 [Print] England
• PMID: 731238 (Publication Type: Journal Article)

Chemical References

• Vasodilator Agents
• Carbon Dioxide
• Phenylpropanolamine

Topics

• Aged
• Blood Pressure (drug effects)
• Brain (blood supply)
• Carbon Dioxide (blood)
• Cerebral Infarction (complications, drug therapy)
• Dementia (drug therapy, etiology)
• Drug Evaluation
• Female
• Humans
• Injections, Intravenous
• Male
• Middle Aged
• Phenylpropanolamine (analogs & derivatives, therapeutic use)
• Regional Blood Flow (drug effects)
• Vasodilator Agents (administration & dosage, therapeutic use)