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Embryonic and foetal myosins in human skeletal muscle. The presence of foetal myosins in duchenne muscular dystrophy and infantile spinal muscular atrophy.

Abstract
Recently described techniques for separating myosin isoenzymes have been adapted for analysis of myosins from diseased and developing human skeletal muscle. The method is highly suitable for analysis of human myosins because only 2 - 3 mg of muscle are required for routine analyses. Human embryonic/foetal myosins are electrophoretically distinct from mature skeletal myosins, and are not normally detected beyond the first month of post-natal life, except in premature infants. They have a high alkaline calcium-activated ATPase activity. This would account for the histochemical classification of foetal fibres as "Type II", although physiological differences between adult fast-twitch muscle and foetal muscle are well recognized. Foetal myosins are also synthesized in human skeletal muscle under certain pathological circumstances. Their presence in Duchenne dystrophy probably reflects the associated marked muscle regeneration, with immaturity of some muscle cells. The large amounts of foetal myosin present in many cases of infantile spinal muscular atrophy is evidence that innervation is necessary for the normal cessation of foetal myosin synthesis.
AuthorsR B Fitzsimons, J F Hoh
JournalJournal of the neurological sciences (J Neurol Sci) 1981 Nov-Dec Vol. 52 Issue 2-3 Pg. 367-84 ISSN: 0022-510X [Print] NETHERLANDS
PMID7310440 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Myosins
Topics
  • Animals
  • Atrophy
  • Electrophoresis, Polyacrylamide Gel
  • Embryo, Mammalian
  • Female
  • Fetus
  • Humans
  • Infant
  • Infant, Newborn
  • Molecular Weight
  • Muscles (analysis, pathology)
  • Muscular Dystrophies (metabolism)
  • Myosins (analysis)
  • Pregnancy
  • Spinal Cord (physiopathology)

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