Lucus B HLA antigens in psoriatic patients. Population and family studies and clinical relationship.

Abstract

The HLA gene and haplotype frequencies in psoriatic population (N = 136) and families (N = 47) were estimated. The significant association with HLA-B17 and B13 was found. The relative risk for these antigens was 4.4 and 2.4, respectively. The most frequent haplotypes carrying the "psoriatic" antigens was HLA-A1, B17 and HLA-A10, B17, with significant relative risk, equalled 8.24 and 5.75. The distribution of HLA-B13 and B17 phenotypes according to the three groups of clinical activity and four groups of extent of skin lesions were considered. The strong association between HLA-B17 and psoriasis with large skin involvement (more than 50%) was observed. The possible role of antigen B17 in pathomechanism of psoriasis is discussed.

• Authors: G Turowski, J J Pietrzyk, M Kapińska-Mrówka
• Journal: Archives of dermatological research (Arch Dermatol Res) Vol. 271 Issue 3 Pg. 315-24 ( 1981) ISSN: 0340-3696 [Print] Germany
• PMID: 7305443 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• HLA Antigens

Topics

• Adolescent
• Adult
• Aged
• Child
• Child, Preschool
• Female
• Genes
• HLA Antigens (analysis)
• Haploidy
• Humans
• Male
• Middle Aged
• Phenotype
• Poland
• Psoriasis (genetics, immunology)
• Risk