Heart lipidosis induced by short-term feeding of cis- or trans-docosenoic acids in weanling or 7-week-old rats.

Abstract

Weanling male rats were fed calcium-deprived diets containing 15% lipids, of which half is cis- or trans-docosenoic acid, for 5, 12 or 28 days. Elaidic or oleic acid-fed rats served as controls. After 5 days on diet, the rats fed brassidic acid showed heart triglyceride accumulation, but less than the erucic acid-fed rats. In both groups, the heart triglyceride content decreased with time and returned to normal values after 28 days. When similar diets were fed for 12 days to 7-week-old rats, brassidic acid, on the contrary, induced a greater triglyceride accumulation than erucic acid did.

• Authors: P O Astorg
• Journal: Annals of nutrition & metabolism (Ann Nutr Metab) Vol. 25 Issue 4 Pg. 201-7 ( 1981) ISSN: 0250-6807 [Print] Switzerland
• PMID: 7305284 (Publication Type: Journal Article)

Chemical References

• Erucic Acids
• Fatty Acids
• Fatty Acids, Unsaturated
• Triglycerides

Topics

• Animals
• Body Weight (drug effects)
• Cardiomyopathies (chemically induced)
• Diet
• Erucic Acids (pharmacology)
• Fatty Acids (analysis)
• Fatty Acids, Unsaturated (pharmacology)
• Lipidoses (chemically induced)
• Male
• Rats
• Rats, Inbred Strains
• Stereoisomerism
• Triglycerides (metabolism)