Coagulopathy associated with hematin treatment for acute intermittent porphyria.

Abstract

Hematin has been shown to be effective therapy for acute intermittent porphyria. Few complications have been found. We cared for a patient who developed a markedly prolonged prothrombin time, partial thromboplastin time, thrombocytopenia, mild hypofibrinogenemia, mild elevation of fibrin split products, and a 10% fall in hematocrit while receiving hematin. No other cause for the coagulopathy could be found. The abnormal coagulation variables returned to normal when hematin was discontinued. Patients receiving hematin for acute intermittent porphyria should be closely observed for signs of coagulopathy.

• Authors: D L Morris, M D Dudley, R D Pearson
• Journal: Annals of internal medicine (Ann Intern Med) Vol. 95 Issue 6 Pg. 700-1 (Dec 1981) ISSN: 0003-4819 [Print] United States
• PMID: 7305149 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Heme
• Hemin

Topics

• Acute Disease
• Adult
• Blood Coagulation Disorders (chemically induced)
• Female
• Heme (analogs & derivatives)
• Hemin (adverse effects, therapeutic use)
• Humans
• Porphyrias (drug therapy)
• Recurrence