Resuscitation with pyridoxalated stroma free hemoglobin: tolerance to sepsis.

Abstract

The contribution of the reticuloendothelial system (RES) in pyridoxalated stroma-free hemoglobin (SFH-P) clearance may be insignificant. The magnitude of this is not at present clear. Any compromise of RES function would militate against its potential benefit as an oxygen-carrying resuscitation fluid. The relationship between lethal hemorrhagic shock resuscitation with SFH-P and subsequent host depression was examined in a rat model. Host tolerance to a standard intra-abdominal polymicrobial septic challenge was assessed 5 days after hemorrhagic shock. Shock resuscitation with pyridoxalated stroma-free hemoglobin was equal to or better than all other resuscitation groups evaluated. Tolerance to a standard septic challenge 5 days after resuscitation was no different between resuscitation groups. There appears to be no compromise to host defense in general in tolerating intra-abdominal sepsis 5 days following shock resuscitation with pyridoxalated stroma-free hemoglobin.

• Authors: D B Hoyt, A G Greenburg, G W Peskin, S Forbes, H Reese
• Journal: The Journal of trauma (J Trauma) Vol. 21 Issue 11 Pg. 938-42 (Nov 1981) ISSN: 0022-5282 [Print] United States
• PMID: 7299862 (Publication Type: Journal Article)

Chemical References

• Hemoglobins
• Pyridoxal

Topics

• Animals
• Hemoglobins (metabolism, therapeutic use)
• Mononuclear Phagocyte System (drug effects, physiology)
• Pyridoxal (pharmacology)
• Rats
• Rats, Inbred Strains
• Resuscitation (methods)
• Sepsis (immunology)
• Shock, Hemorrhagic (therapy)